We know from genetic research that cells and tissues do not develop normally without microRNAs. Abnormal regulation by microRNA can contribute to cancer, and mutations in genes coding for microRNAs have been found in humans, causing conditions such as congenital hearing loss, eye and skeletal disorders,
Their groundbreaking discovery revealed a completely new principle of gene regulation that turned out to be essential for multicellular organisms, including humans,
If we take the example of cancer, we’ll have a particular gene working overtime, it might be mutated and working in overdrive,
Well, I just kept repeating in my mind, this changes everything because you know, the Nobel is just mythic in how it transforms the life of people who are selected,
There’s a trip coming up. It will be the third, possibly the best,
Somebody called my son, who called my wife as my phone was downstairs,
If we can intervene at the microRNA level, it opens up a whole new way of us developing medicines,
It represents the recognition of how wonderful and unexpected discoveries come from a curiosity in basic science financed by taxpayer money. It’s a vitally important, probably the most important message, that this investment really pays off,
The seminal discovery of microRNA has introduced a new and unexpected mechanism of gene regulation,
It seems very likely that microRNAs have important roles in why the human brain is different from the brains of other primates,
This was not just something weird that worms do, but in fact all animals and plants are totally dependent for development and normal function on them,
The discovery of microRNAs brought an additional level of complexity by revealing that regions that were thought to be non-coding play a role in gene regulation,
Though there are no very clear applications available yet in microRNAs, understanding them, knowing that they exist, understanding their counter-regulatory networks, is always the first step,
Nobody really paid much attention,
This was a whole new level of control that we had totally missed,
It took a long time before he came to the phone and sounded very tired, but he quite rapidly was quite excited and happy, when he understood what it was all about,
MicroRNA alters how genes in the cell work,
The majority of therapies we have at the moment are targeting proteins in cells,
The Nobel's, you know, there's a word we use for Major League Baseball, it's called 'The Show'. Which means it's not any show, it's THE show,
That's been great. He's a wonderful guy,